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Alizyme Announces Successful Preliminary Results from Its Phase ...

... Mucositis Treatment of cancer with chemotherapy or radiotherapy can result in mucositis, a condition in which the cells lining the mouth and gastrointestinal tract are damaged leading to inflammation, ulceration, pain, diarrhoea and difficulty in eating and drinking.

An effective drug would greatly improve the quality of life for those receiving cancer treatment.

Also, by reducing the incidence and/or severity of mucositis, this would allow higher therapeutic doses to be administered and lead to more effective treatment.

Over one million of the cancer patients treated each year suffer from mucositis and the potential market for drugs to prevent/treat mucositis effectively is estimated to be in excess of $500 million per annum.

WHO (World Health Organisation) Oral Mucositis Grades The WHO is a 5 point scale ranging from 0 (no mucositis) to Grade 4 (unable to take fluids or solids by mouth).

Intermediate points on the scale include other components, such as: ulceration, pain and bleeding.

Western Consortium for Cancer Nursing Research (WCCNR) Grades The WCCNR is a 4 point scale, ranging from 0 (no mucositis), to Grade 3 (includes: ulceration, bleeding, infection, inability to take fluids and solids by mouth, and pain).

Intermediate points include all these symptoms, but with lower degrees of severity.

Autologous Peripheral Blood Stem Cell Transplantation (PBSCT) Autologous PBSCT involves removal of some stem cells from the blood of a c...

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