Ulcerative Colitis

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About Callisto Pharmaceuticals, Inc.

Callisto is a biopharmaceutical company focused on the development of new drugs to treat various forms of cancer and other serious afflictions.

Callisto's drug candidates in development currently include anti-cancer agents in clinical development, in addition to drugs for a range of other significant health care market segments, including biodefense.

One of the Company's lead drug candidates, L-Annamycin, is being developed as a treatment for forms of relapsed leukemia, a currently incurable blood cancer.

Callisto initiated a clinical trial of L-Annamycin in adult relapsed acute lymphocytic leukemia patients in 4Q 2005.

L-Annamycin, a new compound from the anthracycline family of proven anti-cancer drugs, has a novel therapeutic profile, including activity against resistant diseases and significantly reduced cardiotoxicity, or damage to the heart, compared to currently available drug alternatives.

Another anti-cancer drug, Atiprimod, is in development to treat relapsed multiple myeloma, a blood cancer.

Atiprimod has entered Phase I/IIa human clinical trials in relapsed multiple myeloma patients.

Callisto also has drug...

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Ana became a national rallying point to help undocumented children in need of an organ transplant due to life-threatening illnesses.

In a powerful way, her case revealed the harsh reality of seriously ill children of undocumented parents who do not have access to federal aid and lack adequate health insurance.

This issue now has become part of the national debate regarding immigration reform and how the United States must deal with more than 11 million undocumented people currently living in the country.

Ana was undocumented in the United States.

Her mother emigrated with her from Aguascalientes, Mexico, and settled in Chicago in 1992.

Although Children's Memorial Hospital treated Ana's liver disease for two years, the hospital could not perform the $500,000 surgery because Medicaid would not reimburse the amount.

Emergency and medical care are provided to undocumented people under the Social Security Act of 1997, but the law does not cover organ transplants.

That sparked one of the most amazing community efforts to save a child's life regardless of her immigration status.

In April of 2001, the Spanish language weekly Exito, owned by Tribune Co.

and the predecessor of the daily Hoy Chicago, published Ana's photograph on the cover with ...